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MOLECULAR BASIS OF CELL CYCLE REGULATION BY CYCLIN : A SHORT REVIEWAuthor Name: Soma Susan Varghese, Jithin Jose, Philips Mathew,
Abstract: Eukaryotic cell cycle is under the control of Cyclin Dependent Kinase enzymes which is regulated positively by Cyclins and negatively by inhibitors of Cyclin Dependent Kinase (CDK). pRB, the fundamental component of cell cycle restriction point is phosphorylated and dephosphoryated by Cyclin Dependent Kinase enzyme. CDKI(p21) is transcriptionaly regulated by p53,which focus on the major role of Cyclin on cell cycle check point cascade. Dysregulation of normal cell cycle pathway can result in carcinogenesis.
Keywords: Cyclin, dependend, kinase, cyclin, Phostho relation.
OBSTRUCTIVE SLEEP APNOEA AND MAXILLOFACIAL SURGERYAuthor Name: Fiaz Shemshudeen, Joju George
Abstract: Obstructive sleep apnoea (OSA) is a disease of the upper airways that leads to a cessation of or a significant decrease in breathing during sleep leading to increased fatigue, difficulty in concentrating and in some cases leading to cardiovascular diseases and even stroke. It affects millions of people around the world. This condition in many of the individuals remain undiagnosed while those who are diagnosed often exhibit poor compliance with the use of Continuous Positive Air Pressure (CPAP), a very effective non-invasive modality. Maxillo-mandibular advancement(MMA) surgery is the most successful treatment for the severe form of this disease. This article reviews various Oral and Maxillofacial management options for the treatment of OSA.
Keywords: Obstructive Sleep Apnea, Maxillo- Mandibular Advancement, Continuous positive airway pressure.
OBLIQUE FRACTURE OF PARASYMPHYSIS CASE REPORT AND MANAGEMENTAuthor Name: Anoop Kurian Mathew, Anis Ahmed
Abstract: Mandibular fractures are more common among maxillofacial trauma. Fractures of the para symphyseal region of mandible occur in15% of all cases of mandibular fracture. The diagnosis of mandibular fractures must begin with a careful history and clinical examination. Mandible is one of the strongest bone of facial skeleton, but it is frequently fractured due to its prominent position, mobility, anatomic configuration as well as less bone support. This paper presents a case report with a facial trauma affecting the mandibular para symphysis with an emphasis on its management.
Keywords: Fracture, Mandibular parasymphysis, ecchymosis
PROSTHETIC MANAGEMENT OF A UNILATERAL CLEFT PALATE PATIENT A CLINICAL REPORT ABSTRACTAuthor Name: Mohammed Shahid, Nidhin Alex, Fathima Seethi, Afsa Ahmed
Abstract: Cleft lip and palate is a congenital deformity that is associated with maxillary discrepancies along with dental anomalies. Patients who have not received treatment early in life are the most challenging to treat prosthetically later in life. These patients can be managed prosthetically by obturator prosthesis. this article reviews the management of cleft palate with a closed hollow bulb obturator prosthesis and the steps involved in its fabrication.
Keywords: Unilateral cleft lip and palate, Maxillary hollow bulb obturator , functional and aesthetic corrections
APEXIFICATION USING MINERAL TRIOXIDE AGGREGATE CASE REPORTAuthor Name: Varun Mathew Manakunnath, Romel Joseph, Dinesh Kamath, Ajay Joseph
Abstract: It is difficult to treat immature teeth with necrotic pulp and periapical lesion through conventional endodontic treatment. Use of calcium silicate material in dentistry became popularised due to various chemical application and its inherent advantage namely biocompatibility, sealing ability, regenerative capacity and antibacterial characteristics. Previously calcium hydroxide was used for apexification but due to its drawbacks modified calcium silicate was introduced to overcome these difficulties.
Keywords: Apexification, calcium silicatemineral trioxide aggregate.