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Original Research Article
DIAGNOSTIC VALUE OF AUTO ANTIBODIES IN PATIENTS WITH RHEUMATOID ARTHRITISAuthor Name: Dhanya P, Sudheesh M
Abstract: Arthritis, an autoimmune disease, is a form of joint disorder which involves inflammation of one or more joints causing many complications. Early diagnosis of rheumatoid arthritis (RA) is important in order to prevent crippling and also helps the accurate interpretation of medical history and clinical examination. A study was conducted to find out the involvement of CCP Antibodies in RA suspected individuals. The level of CCP was determined in clinically suspected RA patients. In addition, the level of Rheumatoid Arthritis Factor and CRP level of the patients were also determined. A total of 110patients with clinically suspected RA are included in the study. Anti CCP and RA measured and CCP positivity was compared in RAF positive and negative individuals. CRP level was measured in CCP positive patients. 40% of the clinically suspected RA patients were positive for RF. Thus it is concluded that among clinically suspected RA patients, measurements of CCP antibody is more specific for diagnosis. Substantial proportions have elevated CRP levels which are associated with high risk for future cardiovascular events.
Keywords: Rheumatoid arthritis, CCP antibodies, CRP level, fillagrin, ELISA.
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SOLITARY NEUROFIBROMA ON THE FLOOR OF THE MOUTH: A RARE CASE REPORT AND REVIEW OF LITERATUREAuthor Name: Nirupa Thomas, Asif Ismail, John Joseph Methippara
Abstract: Neurofibroma is an uncommon benign tumor of oral cavity derived from cells that constitute nerve sheath. The cases of oral cavity that involves neurofibroma with no other signs of neurofibromatosis is rare. Neurofibromas may present either as a solitary lesions or as a part of the generalised syndrome of neurofibromatosis or Von Recklinghausen's disease of the skin. Clinically, oral neurofibromas usually appear as a pedunculated or as sessile nodules, with slow growth and mostly without pain. The diagnosis can be confirmed by histological examination. Neurofibromas are immunopositive for the S-100 protein, indicating its neural origin. Treatment is surgical and the prognosis is excellent. Neurofibroma arising from the floor of the mouth is extremely rare. Here we present an unusual case of neurofibroma of the floor of the mouth.
Keywords: solitary neurofibroma, neurofibromatosis, immunohistochemistry
OSTEOMA: A RARE CASE REPORTAuthor Name: Sanju L, Shilpa C, Eldhose K George
Abstract: Osteomas are rare, benign, slow growing tumors characterised by the proliferation of compact or cancellous bone. It accounts for3% of primary bone tumors, and about 10% of benign tumors. About 80% of osteoid osteoma occurs in long bones, while less than1% occur in Jaw. The mandible is more commonly affected than the maxilla, with the site predilection being the lingual aspect of the body, the angle and the inferior border of the mandible. In this paper we present an osteoma located in the lingual surface of the right mandible in a 44 year old woman and which was surgically excised.
Keywords: Peripheral osteoma, Hard swelling, Mandible.
OSTEOMYELITIS AS A RARE COMPLICATION OF HERPES ZOSTER INFECTION ASSOCIATED WITH NEURALGIAAuthor Name: Ajish George Oommen, Fiaz Shamsudheen, Joju George
Abstract: Herpes zoster is caused by reactivation of latent varicella zoster virus in cranial-nerve or dorsal-root ganglia, with spread of the virus along the sensory nerve to the dermatome. Osteomyelitis of the jaws as a complication of herpes zoster infection is a rare finding. The aim of this paper is to review the literature regarding osteomyelitis as an unusual complication secondary to herpes zoster and to present a case report of this complication in an immunocompetent patient. A 52 year-old male patient presented with herpetic neuralgia of mandibular & maxillary divisions of trigeminal nerve with associated osteomyelitis of left side of mandible. Patient was treated with antivirals, antibiotics, carbamazepine with curettage and debridement. Osteomyelitis of the jaws as a complication of herpes zoster infection is a rare finding. The etiopathogenesis of herpes induced osteomyelitis is controversial and research in this aspect is hindered by limited sample size. Through this case report we try to present a rare case of osteomyelitis as a complication of herpes zoster infection. Further research with randomized control trials is warranted for better management of this condition.
Keywords: Osteomyelitis, Neuralgia, Hepres zoster, Mandible, Trigeminal nerve.